Drug metabolism is inhibited only in severe hepatitis, and exceptionally in liver cirrhosis because.....

Question

A.               The body has not been vaccinated.

B.               Hepatocytes cannot produce adequate of liver enzymes.

C.               Cirrhosis will cause ascites.

D.               All of the above

Answer 1

B. Hepatocytes cannot produce adequate liver enzymes.

In severe hepatitis and liver cirrhosis, the liver undergoes significant damage and dysfunction. Hepatocytes, the main functional cells of the liver, are responsible for drug metabolism. In these conditions, the liver cells may be unable to produce an adequate amount of liver enzymes necessary for drug metabolism. This impairment can lead to a decrease in the metabolism and clearance of drugs from the body, potentially resulting in increased drug toxicity and adverse effects.

Option A (The body has not been vaccinated) is unrelated to drug metabolism and is not a factor contributing to its inhibition in hepatitis or cirrhosis.

Option C (Cirrhosis will cause ascites) refers to the accumulation of fluid in the abdominal cavity, which is a complication of liver cirrhosis but is not directly related to the inhibition of drug metabolism.