His book ‘Charak Samhita’ which was written in 200 BC is still a much revered book in the field of medicine. This is one of the oldest books in Sanskrit. This book is divided into 8 parts and has both verses and prose. Charak was familiar with the fundamental concepts of inheritance. He also discovered the concept of sex determination of a child. He had postulated that any genetic defect in a child happens because of some deficiency or defect in parents. He was the first to claim that heart was the control centre of body and is attached with main arteries.
In Charak Samhita, he has also mentioned some instructions and oaths for the doctors and for students of medicine. He advocated that doctors should not develop enmity with their patients under any circumstance. A doctor should never leak out any personal or family matter of the patient. A doctor should always be ready to accept a new knowledge.