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Name the Europeans who first conquered America in the mid- 16th century.

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Portugal and Spain

The two European countries of Portugal and Spain had conquered a vast portion of America in the mid 16 century. This conquest was possible due to the superior quality of military equipment, Apart from this, another unconventional reason for conquest was the germs of smallpox, carried by Europeans to America. Since the people living in America lived in isolation and did not have any immunization against it, it led to the spread of smallpox among them. Eventually, many people died in America, which further strengthen their conquest.

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